PATHOPHYSIOLOGY OF BLEEDING DIATHESIS IN HAEMOPHILIA-A: A SEQUENTIAL AND CRITICAL APPRAISAL OF NON-FVIII RELATED HAEMOSTATIC DYSFUNCTIONS AND THEIR THERAPEUTIC IMPLICATIONS

Pathophysiology of bleeding diathesis in haemophilia-A: A sequential and critical appraisal of non-FVIII related haemostatic dysfunctions and their therapeutic implications

Haemophilia-A is characterized by deficiency of FVIII, but the bleeding diathesis is not a mere reflection low FVIII activity.The pathophysiology of haemophilic bleeding diathesis is a complex interplay between defective procoagulant function and up-regulated fibrinolysis.Moreover, haemophilic bleeding diathesis is frequently compounded by treatmen

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ON OPTIMUM DESIGN OF FRAME STRUCTURES

Optimization of VOLUMIZING CONDITIONER frame structures is formulated as a non-convex optimization problem, which is currently solved to local optimality.In this contribution, we investigate four optimization approaches: (i) general non-linear optimization, (ii) optimality criteria method, (iii) non-linear semidefinite programming, and (iv) polynom

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